1079M

Psychiatr. Pol. 2017; 51(6): 1079–1093

DOI: https://doi.org/10.12740/PP/74358

Dorota Mehrholz, Anna Emilia Urban,Marta Herstowska,
Roman Nowicki, Wiesław Cubała, Wioletta Barańska-Rybak

FREE POLISH FULLTEXT:

Analiza retrospektywna DRESS – reakcji polekowej z eozynofilią i powikłaniami narządowymi

FREE ENGLISH FULLTEXT:
A retrospective study of DRESS – drug reaction with eosinophilia and systemic symptoms

Summary
Aim: DRESS (drug reaction with eosinophilia and systemic syndrome) is qualified as hypersensitivity reactions to drugs. This syndrome may occur due to any medication intake. There are three main groups of symptoms defining DRESS: skin lesions, hematological abnormalities and internal organ involvement.
Method: A retrospective study was performed on a group of 261 patients with drug reactions hospitalized in the Department of Dermatology from 2004 until 2017.
Results: There were ten cases of DRESS among 261 hypersensitivity drug reactions observed in the Department. The drug which most frequently caused DRESS in the studied group was carbamazepine–six patients (60%). Lamotrigine was the cause of DRESS in two cases, oxycarbamazepine in one patient and dexketoprofen in one patient. The skin lesions were present in 100% patients. Mainly it was erythematous confluent rash accompanied by face edema. Eosinophilia was noticed in 80% of patients and the presence of atypical lymphocytes – in 40%. The main infiltrate organ was liver.
Conclusions: DRESS diagnosis should be taken into consideration especially in patients treated with antiepileptic drugs. Early diagnosis and drug discontinuation can contribute to preventing serious complications of DRESS.


ISSN 0033-2674 (PRINT)

ISSN 2391-5854 (ONLINE)


Psychiatria Polska
is an Open Access journal:
Creative Commons: CC-BY
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Zadanie finansowane
w ramach umowy
nr 739/P-DUN/2018
ze środków MNiSW
przeznaczonych
na działalność
upowszechniającą naukę



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