1117_1126
Psychiatr. Pol. 2014; 48(6):1117–1126DOI: http://dx.doi.org/10.12740/PP/31394
Agnieszka Permoda-Osip, Jacek Kisielewski, Jolanta Dorszewska, Janusz Rybakowski
FREE POLISH FULLTEXT:
Homocysteina a funkcje poznawcze w depresji w przebiegu choroby afektywnej dwubiegunowej
FREE ENGLISH FULLTEXT:
Homocysteine and cognitive functions in bipolar depression
Abstract
Objectives. The aim of the study was to evaluate a relationship between concentrations of hoocysteine (HCY), vitamin B12 and folic acid and disturbances of cognitive functions during acute episode of bipolar depression.
Methods. 116 patients were studied (93 women, 23 men), aged 20-78 (mean 51±13) years during acute episode of bipolar depression. Depression was evaluated by the 17-item Hamilton's Depression Rating Scale (HDRS). The following tests measuring cognitive functions were applied: Trail Making Test, Wisconsin Card Sorting Test, Stroop Test and Wechsler Adult Intelligence Scale-Revised. In all patients, the measurements of serum homocysteine, vitamin B12 and folic acid were carried out.
Results. Hyperhomocystemia (HCY>15μM/l) was detected in 41 patients (35%), more frequently in men (52%) than in women (31%). Patients with hyperhomocysteinemia achieved worse results in sub-tests of WAIS-R (verbal understanding and perceptional organization). In men, negative correlation was found between HCY concentration and number of errors in Stroop Test, and WCST (total errors and non-perseverative errors). In women with bipolar disorder, type II, negative correlation between HCY concentration and time of Stroop Test, and between vitamin B12 concentration and number of errors in Stroop Test, were demonstrated. In the whole group and in men, there was positive correlation between higher folic acid concentration and the number of errors in Stroop Test.
Conclusions. The results obtained show higher HCY concentration in considerable proportion of patients with bipolar depression, especially in men. They also confirm a connect between high homocysteine concentration and worse performance in some neuropsychological tests. Such relationship was more marked in men.
ISSN 0033-2674 (PRINT)
ISSN 2391-5854 (ONLINE)
Psychiatria Polska
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue

Zadanie finansowane
w ramach umowy
nr 739/P-DUN/2018
ze środków MNiSW
przeznaczonych
na działalność
upowszechniającą naukę
KRW PTP dziękuje
firmie PPL – Koral – J.Koral sp.j.
za wsparcie finansowe
udzielone w 2020 roku
Inne strony PTP:
Other PTP websites:
www.psychiatria.org.pl
www.psychiatriapsychoterapia.pl
www.archivespp.pl
www.psychoterapiaptp.pl
Psychiatria Polska
INDEXED IN:
Thomson Reuters Master List
Science Citation Index Expanded
Journal Citation Reports
(Impact Factor 1,190)
Medline/Index Medicus
PubMed/LinkOut
MNiSW (40 pkt)
Scopus/SCImago
(SJR 0,381; SNIP 0,587)
EMBASE/Excerpta Medica
PsycINFO, EBSCO,
Index Copernicus
Erih Plus, Cochrane Library
CrossRef/DOI
We recommend:
Pharmacological Reports