1359_1370
Psychiatr. Pol. 2015; 49(6): 1359–1370DOI: http://dx.doi.org/10.12740/PP/60139
Giovanni Mariscalco, Silvia Mariani, Fausto Biancari, Maciej Banach
FREE POLISH FULLTEXT:
Wpływ statyn na majaczenie w następstwie operacji kardiochirurgicznych – dowody z piśmiennictwa
FREE ENGLISH FULLTEXT:
Effects of statins on delirium following cardiac surgery – evidence from literature
Summary
Delirium is a common complication after cardiac surgery, being associated with significant mortality and morbidity. The pathogenesis of postoperative delirium (POD) is complex and multifactorial, involving an interaction of multiple predisposing and precipitating factors. Thereare several hypothesis regarding the underlying mechanisms of POD, and the most recent emerging one involves neuroinflammation, which is exacerbated by the cardiopulmonary bypass-induced systemic inflammatory response. Experimental and clinical studies have recently documented improved perioperative central neural protection exerted by statins because of their anti-inflammatory, immunomodulatory, and antithrombotic properties. The present review will be focused on the possible protective effect exerted by preoperative statin administration on delirium following cardiac surgery.
ISSN 0033-2674 (PRINT)
ISSN 2391-5854 (ONLINE)
Psychiatria Polska
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue
is an Open Access journal:
Creative Commons: CC-BY
SHERPA RoMEO: Blue

Zadanie finansowane
w ramach umowy
nr 739/P-DUN/2018
ze środków MNiSW
przeznaczonych
na działalność
upowszechniającą naukę
KRW PTP dziękuje
firmie PPL – Koral – J.Koral sp.j.
za wsparcie finansowe
udzielone w 2020 roku
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Psychiatria Polska
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CiteScore 2,4
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